Vol. 12, No. 3 May-June 2001
Stemming the Tide of Misinformation
Chances are you've never heard of Melissa Holley. She's an American teenager whose spinal cord was severed in an auto accident last year, leaving her paraplegic. Today Melissa "has recovered significant motor function in her legs" and regained bladder control, following an injection of immune cells from her own blood into the damaged area of her spinal cord. She's not walking (yet), but the new treatment developed by Proneuron Biotechnologies in Israel marks a startling new advance in restoring function lost by a severe spinal cord injury.
That Melissa's astonishing progress was not front page news may be due to the fact that we're in the middle of a highly politicized debate over federal funding of human embryonic stem cell research. With few exceptions, the national media have chosen sides with pro-funding forces. Reporters and columnists have all but ignored astounding research developments involving cells obtained without injury to the donor-- from, e.g., adult human tissue, umbilical cord blood, placentas, and even the brains of cadavers. At the same time they have trumpeted even modest advances using embryonic stem cells--as if cures were suddenly at hand for "incurable" conditions like diabetes, paralysis, Parkinson's and Alzheimer's--and downplayed the negative scientific and ethical aspects of using these cells.
Examples of this media bias were detailed in May by the Statistical Assessment Service (STATS), a non-partisan, non-profit research organization devoted to the accurate use of scientific and social research in public policy debate.
One example STATS cited was a report that mouse embryonic stem cells had been programmed to secrete insulin, supposedly pointing to a cure for diabetes (Science, April 2001). This received wide and enthusiastic media coverage. But no mention was made of a much more significant development more than a year earlier, in which adult mouse pancreatic stem cells successfully reversed diabetes in the mice (Nature Medicine, March 2000).
And journalists neglected to mention that the mice receiving the embryonic stem cells still died from diabetes (a point which diabetics might find relevant). Nor has there been coverage of further developments here and abroad where ductal tissue from adult human pancreas has produced insulin-secreting islet buds in culture.
Unless you read science journals, you would not know that amazing advances in research using non-embryonic stem cells are occurring rapidly. A few examples:
Such discoveries mean that real cures for debilitating conditions are possible in the foreseeable future.
How many therapeutic successes can scientists point to using embryonic stem cells in clinical trials on humans? Zero. At a June 22 workshop, "Stem Cells and the Future of Regenerative Medicine," sponsored by the National Academy of Sciences' Institute of Medicine, the chairman of the Institute's committee studying stem cell research, Bert Vogelstein, M.D. (professor of oncology and pathology and Johns Hopkins University), said all claims of therapeutic benefit from embryonic stem cell research are "conjectural." He added, "there is no experience with embryonic stem cells in humans, and very little in mice."
Marcus Grompe, M.D., Ph.D., Department of Molecular and Medical Genetics, Oregon Health Sciences University concurred: "There is no evidence of therapeutic benefit from embryonic stem cells."
Why then have the national media, with few exceptions, talked only about advances with embryonic stem cells? Why have they been loathe to admit that embryos are something more than disposable clumps of cells? Maybe they fear that the precarious edifice of abortion rights could topple, and that the great god, Science, may be restrained by "conventional" and "outdated" morality.
The new morality, underlying many editorials, can be reduced to one commandment: The end justifies the means.
Of Lice and Supermen
Anna Quindlen, New York Times columnist, wore her utilitarian heart on her sleeve when she wrote: "It may be an oversimplification to say that real live loved ones trump the imagined unborn, that a cluster of undifferentiated cells due to be discarded anyway is a small price to pay for the health and welfare of millions. Or perhaps it is only a simple commonsensical truth."
She echoes Raskolnikov's rationale for killing an old pawnbroker: "Dozens of families [might be] saved. ... Take her money and with the help of it, devote oneself to the service of humanity and the good of all. ... Besides, what value has the life of that sickly, stupid, ill-natured old woman [or undifferentiated "fertilized egg"] in a balance of existence?" (Dostoevsky, Crime and Punishment).
Raskolnikov liked to think of himself as one of the "extraordinary men" who have the right to commit crimes in pursuit of their great ideas. But after killing the pawnbroker and her sister, he discovers that he was not a superman, just a "louse."
And history offers endless examples of what happens when groups of humans are treated as "less than humans," as objects for others' use and destruction.
The path we should walk is clear. We must resist efforts to kill. We must resist the justification of killing human embryos through appeals to the "greater good" of patients or society. And we should support important legislation like the "Responsible Stem Cell Research Act of 2001," sponsored by Congressman Chris Smith, allocating $30 million for stem cell research from non-embryonic sources and creating a "cell donor bank" to serve researchers nationwide.
Over 24,000 people have signed a petition to President Bush on this issue, organized by the Coalition of Americans for Research Ethics (at www.stemcellresearch.org). In fact, why not sign up today? And let the White House know what you think.

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